Evidence of an Association Between the Scavenger Receptor Class B Member 2 Gene and Parkinson's Disease
Identifieur interne : 001126 ( Main/Exploration ); précédent : 001125; suivant : 001127Evidence of an Association Between the Scavenger Receptor Class B Member 2 Gene and Parkinson's Disease
Auteurs : Helen Michelakakis [Grèce] ; Georgia Xiromerisiou [Grèce] ; Efthimios Dardiotis [Grèce] ; Maria Bozi [Grèce] ; Demetrios Vassilatis [Grèce] ; Persa-Maria Kountra [Grèce] ; Gianna Patramani [Grèce] ; Marina Moraitou [Grèce] ; Dimitra Papadimitriou [Grèce] ; Eleftherios Stamboulis [Grèce] ; Leonidas Stefanis [Grèce] ; Elias Zintzaras [Grèce, États-Unis] ; Georgios M. Hadjigeorgiou [Grèce]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Lysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose-6-phosphate-independent receptor for glucocerebrosidase (β-GCase); a deficiency in this protein causes Gaucher disease. Several studies have shown a link between mutations in the β-GCase gene and diseases characterized clinically by Parkinsonism and by the presence of Lewy body-related pathology. We hypothesized that genetic variants in the SCARB2 gene could be risk factors for Parkinson's disease (PD). A candidate-gene study of 347 Greek patients with sporadic PD and 329 healthy controls was conducted to investigate the association between 5 polymorphisms in the SCARB2 gene (rs6824953, rs6825004, rs4241591, rs9991821, and rs17234715) and the development of PD. The single-locus analysis for the 5 polymorphisms revealed an association only for the rs6825004 polymorphism: the generalized odds ratio (ORG) was 0.68 (95% confidence interval [CI], 0.51-0.90), and the OR for the allelic test was OR = 0.71 (95% CI, 0.56-0.90). Haplotype analysis showed an association for the GCGGT haplotype (P < .01). Our study supports a genetic contribution of the SCARB2 locus to PD; future studies in larger cohorts are necessary to verify this finding.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000216
- to stream PascalFrancis, to step Curation: 002A98
- to stream PascalFrancis, to step Checkpoint: 000199
- to stream Main, to step Merge: 001178
- to stream Main, to step Curation: 001126
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Evidence of an Association Between the Scavenger Receptor Class B Member 2 Gene and Parkinson's Disease</title><author><name sortKey="Michelakakis, Helen" sort="Michelakakis, Helen" uniqKey="Michelakakis H" first="Helen" last="Michelakakis">Helen Michelakakis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Enzymology and Cellular Function, Institute of Child Health, Aghia Sophidara Children's Hospital</s1><s2>Athens</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics, Institute of Biomedical Research & Technology, CERETETH</s1><s2>Larissa</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics, Institute of Biomedical Research & Technology, CERETETH</s1><s2>Larissa</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Second Department of Neurology, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Vassilatis, Demetrios" sort="Vassilatis, Demetrios" uniqKey="Vassilatis D" first="Demetrios" last="Vassilatis">Demetrios Vassilatis</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Cell Biology, Biomedical Research Foundation of the Academy of Athens</s1><s2>Athens</s2><s3>GRC</s3><sZ>5 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Kountra, Persa Maria" sort="Kountra, Persa Maria" uniqKey="Kountra P" first="Persa-Maria" last="Kountra">Persa-Maria Kountra</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Patramani, Gianna" sort="Patramani, Gianna" uniqKey="Patramani G" first="Gianna" last="Patramani">Gianna Patramani</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Moraitou, Marina" sort="Moraitou, Marina" uniqKey="Moraitou M" first="Marina" last="Moraitou">Marina Moraitou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Enzymology and Cellular Function, Institute of Child Health, Aghia Sophidara Children's Hospital</s1><s2>Athens</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Papadimitriou, Dimitra" sort="Papadimitriou, Dimitra" uniqKey="Papadimitriou D" first="Dimitra" last="Papadimitriou">Dimitra Papadimitriou</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Stamboulis, Eleftherios" sort="Stamboulis, Eleftherios" uniqKey="Stamboulis E" first="Eleftherios" last="Stamboulis">Eleftherios Stamboulis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Second Department of Neurology, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Second Department of Neurology, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Cell Biology, Biomedical Research Foundation of the Academy of Athens</s1><s2>Athens</s2><s3>GRC</s3><sZ>5 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Zintzaras, Elias" sort="Zintzaras, Elias" uniqKey="Zintzaras E" first="Elias" last="Zintzaras">Elias Zintzaras</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Biomathematics, University of Thessaly School of Medicine</s1><s2>Larissa</s2><s3>GRC</s3><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics, Institute of Biomedical Research & Technology, CERETETH</s1><s2>Larissa</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0198683</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0198683 INIST</idno><idno type="RBID">Pascal:12-0198683</idno><idno type="wicri:Area/PascalFrancis/Corpus">000216</idno><idno type="wicri:Area/PascalFrancis/Curation">002A98</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000199</idno><idno type="wicri:doubleKey">0885-3185:2012:Michelakakis H:evidence:of:an</idno><idno type="wicri:Area/Main/Merge">001178</idno><idno type="wicri:Area/Main/Curation">001126</idno><idno type="wicri:Area/Main/Exploration">001126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evidence of an Association Between the Scavenger Receptor Class B Member 2 Gene and Parkinson's Disease</title><author><name sortKey="Michelakakis, Helen" sort="Michelakakis, Helen" uniqKey="Michelakakis H" first="Helen" last="Michelakakis">Helen Michelakakis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Enzymology and Cellular Function, Institute of Child Health, Aghia Sophidara Children's Hospital</s1><s2>Athens</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics, Institute of Biomedical Research & Technology, CERETETH</s1><s2>Larissa</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics, Institute of Biomedical Research & Technology, CERETETH</s1><s2>Larissa</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Second Department of Neurology, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Vassilatis, Demetrios" sort="Vassilatis, Demetrios" uniqKey="Vassilatis D" first="Demetrios" last="Vassilatis">Demetrios Vassilatis</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Cell Biology, Biomedical Research Foundation of the Academy of Athens</s1><s2>Athens</s2><s3>GRC</s3><sZ>5 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Kountra, Persa Maria" sort="Kountra, Persa Maria" uniqKey="Kountra P" first="Persa-Maria" last="Kountra">Persa-Maria Kountra</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Patramani, Gianna" sort="Patramani, Gianna" uniqKey="Patramani G" first="Gianna" last="Patramani">Gianna Patramani</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Moraitou, Marina" sort="Moraitou, Marina" uniqKey="Moraitou M" first="Marina" last="Moraitou">Marina Moraitou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Enzymology and Cellular Function, Institute of Child Health, Aghia Sophidara Children's Hospital</s1><s2>Athens</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Papadimitriou, Dimitra" sort="Papadimitriou, Dimitra" uniqKey="Papadimitriou D" first="Dimitra" last="Papadimitriou">Dimitra Papadimitriou</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Stamboulis, Eleftherios" sort="Stamboulis, Eleftherios" uniqKey="Stamboulis E" first="Eleftherios" last="Stamboulis">Eleftherios Stamboulis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Second Department of Neurology, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Second Department of Neurology, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Cell Biology, Biomedical Research Foundation of the Academy of Athens</s1><s2>Athens</s2><s3>GRC</s3><sZ>5 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Zintzaras, Elias" sort="Zintzaras, Elias" uniqKey="Zintzaras E" first="Elias" last="Zintzaras">Elias Zintzaras</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Biomathematics, University of Thessaly School of Medicine</s1><s2>Larissa</s2><s3>GRC</s3><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics, Institute of Biomedical Research & Technology, CERETETH</s1><s2>Larissa</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Faculty of Medicine University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological receptor</term><term>Haplotype</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Récepteur biologique</term><term>Haplotype</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose-6-phosphate-independent receptor for glucocerebrosidase (β-GCase); a deficiency in this protein causes Gaucher disease. Several studies have shown a link between mutations in the β-GCase gene and diseases characterized clinically by Parkinsonism and by the presence of Lewy body-related pathology. We hypothesized that genetic variants in the SCARB2 gene could be risk factors for Parkinson's disease (PD). A candidate-gene study of 347 Greek patients with sporadic PD and 329 healthy controls was conducted to investigate the association between 5 polymorphisms in the SCARB2 gene (rs6824953, rs6825004, rs4241591, rs9991821, and rs17234715) and the development of PD. The single-locus analysis for the 5 polymorphisms revealed an association only for the rs6825004 polymorphism: the generalized odds ratio (OR<sub>G</sub>) was 0.68 (95% confidence interval [CI], 0.51-0.90), and the OR for the allelic test was OR = 0.71 (95% CI, 0.56-0.90). Haplotype analysis showed an association for the GCGGT haplotype (P < .01). Our study supports a genetic contribution of the SCARB2 locus to PD; future studies in larger cohorts are necessary to verify this finding.</div></front></TEI><affiliations><list><country><li>Grèce</li><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="Grèce"><noRegion><name sortKey="Michelakakis, Helen" sort="Michelakakis, Helen" uniqKey="Michelakakis H" first="Helen" last="Michelakakis">Helen Michelakakis</name></noRegion><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><name sortKey="Kountra, Persa Maria" sort="Kountra, Persa Maria" uniqKey="Kountra P" first="Persa-Maria" last="Kountra">Persa-Maria Kountra</name><name sortKey="Moraitou, Marina" sort="Moraitou, Marina" uniqKey="Moraitou M" first="Marina" last="Moraitou">Marina Moraitou</name><name sortKey="Papadimitriou, Dimitra" sort="Papadimitriou, Dimitra" uniqKey="Papadimitriou D" first="Dimitra" last="Papadimitriou">Dimitra Papadimitriou</name><name sortKey="Patramani, Gianna" sort="Patramani, Gianna" uniqKey="Patramani G" first="Gianna" last="Patramani">Gianna Patramani</name><name sortKey="Stamboulis, Eleftherios" sort="Stamboulis, Eleftherios" uniqKey="Stamboulis E" first="Eleftherios" last="Stamboulis">Eleftherios Stamboulis</name><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><name sortKey="Vassilatis, Demetrios" sort="Vassilatis, Demetrios" uniqKey="Vassilatis D" first="Demetrios" last="Vassilatis">Demetrios Vassilatis</name><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><name sortKey="Zintzaras, Elias" sort="Zintzaras, Elias" uniqKey="Zintzaras E" first="Elias" last="Zintzaras">Elias Zintzaras</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Zintzaras, Elias" sort="Zintzaras, Elias" uniqKey="Zintzaras E" first="Elias" last="Zintzaras">Elias Zintzaras</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001126 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001126 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0198683
|texte= Evidence of an Association Between the Scavenger Receptor Class B Member 2 Gene and Parkinson's Disease
}}
| This area was generated with Dilib version V0.6.23. |  |